I used to rock a full tower with a custom water loop (there's even pictures buried somewhere deep in this forum). The tower was steel and weighed more than me. It didn't bother me but it did eventually get in the way.
Since then I've been rocking much more modest mid-towers. The problem I find nowadays is everything is already built into the MB so there's no reason to have more than 1 expansion slot for your video card. Take all that extra space, rearrange some of the other components (like power supply) and you can fit the same amount of stuff into a much smaller space. Enter ITX cases.
I also keep my box on my desk so space is at a premium.
Since then I've been rocking much more modest mid-towers. The problem I find nowadays is everything is already built into the MB so there's no reason to have more than 1 expansion slot for your video card. Take all that extra space, rearrange some of the other components (like power supply) and you can fit the same amount of stuff into a much smaller space. Enter ITX cases.
I also keep my box on my desk so space is at a premium.